Dab tsi los cuam tshuam rau cov khoom lag luam ntawm cov siab ceev sib xyaw granulator?
Kev kub ceev ua ke ntawm cov granulator yog hom khoom sib xyaw thiab cov khoom siv roj, uas tuaj yeem siv cov khoom siv sib xyaw ua ke. Hais txog kev siv thev naus laus zis, kev sib xyaw high-speed granulator sib xyaw ua ke ob kauj ruam ntawm kev sib xyaw thiab kev sib txuam, uas tsis tsuas yog txuag lub sijhawm xwb tab sis tseem ua tau raws li GMP cov kev xav, txo qhov sib kis sib kis, thiab txhim kho kev ua tau zoo dua. Cov qauv tau zoo tau txais los ntawm cov neeg siv.
Txawm li cas los xij, piv nrog cov tseev kom muaj ntawm kev tsim qauv tam sim no, cov cuab yeej ib txwm ntawm kev sib xyaw ntawm kev kub ceev thiab kev nrawm nrawm muaj qhov tsis pom tseeb. Nws tau tshaj tawm tias cov khoom siv pabcuam uas siv hauv cov qauv kev ntub dej yog feem ntau txwv cov hmoov qab zib, hmoov txhuv nplej siab, dextrin thiab lwm yam. Ntawm lawv, hmoov qab zib muaj cov hygroscopicity pom tseeb; cov hmoov txhuv yuav maj mam hydrolyze thiab plam nws cov nyhuv o thaum ntsib cov kua qaub, alkali, lossis hauv qab ntawm cov huab cua ntub thiab kub; dextrin cuam tshuam nrog kev txiav txim siab ntawm cov ntsiab lus ntawm qee yam tshuaj, yog li cov tsoos ntub lub granulation Muaj cov kev txwv pom tseeb.
Ntxiv rau, cov txheej txheem ib txwm siv cov kev txiav txim siab hais txog qhov sib npaug ntawm cov rho tawm thiab cov xwm txheej sib txawv los txiav txim cov nyiaj ntawm cov neeg tshaj lij, uas cuam tshuam rau cov qauv tswj kev ua tau zoo ntawm kev npaj. Rau cov tshuaj hygroscopic thiab excipients, yog ntub granulation tshuab yog siv los npaj cov granules, cov granules yuav tau muab zom ua ke, ua rau adhesion, sawb-zoo li cov ntaub ntawv muag, nplaum nets thiab lwm yam tshwm sim. Cov npaj granules yog ib qho nyuaj heev thiab muaj cov solubility tsis zoo thiab tsis zoo. ruaj khov.
Raws li kev lag luam kws kho mob muaj qhov siab dua thiab siab dua rau kev siv tshuab thev naus laus zis, tshuab granulation ntub dej kuj tseem yuav tsum ua kom nrawm nrog lub sijhawm. Tsuas yog kev txuag hluav taws xob ntau, ntau cov kev tiv thaiv ib puag ncig thiab kev nyab xeeb kev lag luam zoo tuaj yeem siv rau hauv kev ua lag luam. Cov kws tshawb nrhiav pom tau tias kev sib xyaw ntawm kev ua kom zoo thiab zoo li qub kom qhuav, uas yog, ob-kauj ruam kom qhuav siv nyob rau hauv cov txheej txheem ziab ntawm cov ntub dej granulation, tuaj yeem ua kom luv lub sij hawm ziab ntawm cov granules ntub thiab nce cov khoom lag luam ntau lawm.
Nws to taub tias cov granules ua los ntawm kev sib xyaw ua haujlwm siab thiab cov granulation muaj cov duab tsis xwm yeem, cov teeb me me thiab qhov loj me, thiab cov qauv zoo dua li lwm cov txheej txheem granulation tsoos, tab sis lawv cov khoom granulated yuav cuam tshuam los ntawm ntau yam.
Ua ntej, kev ceev ntawm cov hniav nyem thiab txiav riam. Raws li kev lag luam, qhov loj thiab faib ntawm qhov loj me me yog ncaj qha ntsig txog qhov nrawm ntawm daim nplawm ntsej muag thiab rab riam txiav. Thaum lub nrawm ntawm kev txiav hniav qeeb, lub particle loj tau loj, thiab thaum qhov nrawm nrawm, qhov loj npaum li cas me dua; thaum qhov ceev ntawm cov nplawm ntsej muag qeeb, Lub particle loj me, thiab qhov ceev nrawm yog, qhov loj dua qhov loj me me kuj muaj. Ob txoj haujlwm yog sib txawv.
Thib ob, cawv ntawm kev sib xyaw thiab cov txheej txheem sib xyaw thiab cov sijhawm. Thaum lub sijhawm ua haujlwm ntawm kev sib xyaw ntawm kev kub ceev thiab tshuab granulating, kev sib hloov ntawm cov nplawm ntawm cov khoom ua kom cov khoom hauv lub lauj kaub yob mus rau qhov chaw, yog li cov ntaub ntawv hauv qab tau muab pov tseg raws phab ntsa ntawm lub lauj kaub, thiab qhov kev ua no successively mos. Cov khoom mos mos yog thawb mus rau txoj kev txiav nrawm nrawm thiab txiav rau hauv qhov me me ntawm ntau qhov sib txawv. Raws li cov lus yob hla lub sijhawm, lawv tau puag ncig thiab maj mam dhau los ua kheej kheej. Nws tuaj yeem pom tau tias qhov nrawm thiab lub sij hawm ntawm cov hniav nyem thiab txiav rab riam cuam tshuam los ntawm kev tawg ntau.
Thib peb, tus yam ntxwv ntawm cov khoom thiab kev xav. Hauv kev tsim cov ntub dej sib xyaw, kev haus cawv ntau lossis dextrin binder granulation feem ntau siv, tab sis muaj qee qhov sib txawv ntawm ob hom kev granulation. Cov dej cawv feem ntau siv rau kev sib tsoo. Vim tias cov cawv tsis muaj viscosity thiab nws muaj cov nyhuv loining, cov qauv no zoo tagnrho rau granulating tshuaj suav cov tshuaj suav nrog viscosity siab. Yog hais tias dextrin yog siv rau kev granulation, vim tias dextrin yog khov thiab muaj lub ntsej muag polymerization, cov khoom tsim tau loj thiab ntxhib, thiab lub ziab qeeb. Hom no zoo tagnrho rau cov tshuaj thaj tsis muaj viscosity.
Tsis tas li ntawd, txawm hais tias nws yog siv los ua cov khoom siv tom qab kev daws teeb meem ntawm cov tshuaj extract, los yog siv cov dextrin lossis lwm cov khoom siv binder, thaum ua cov khoom me me, cov tshuaj slurry concentration ntawm cov khoom tuaj yeem ua thinner, thiab thaum cov khoom loj xav tau, cov khoom siv slurry concentration yuav ua tau me ntsis thicker.