Yuav ua li cas kom ntseeg tau qhov zoo tshaj ntawm cov khoom npaj tau? Npaj thev naus laus zis thiab cuab yeej siv muab cov lus teb
Hauv cov tshuaj lag luam tshuaj, kev npaj khoom tawv yog ib hom tshuaj uas muaj ntau daim ntawv thov thiab ntau yam, suav txog 70% txog 80%. Txij li thaum pib cov khoom siv ntawm cov khoom ua tau yog hmoov, txhawm rau kom cov khoom ua tau zoo thiab cov txheej txheem ntau lawm ntawm kev npaj cov khoom, nws yog feem ntau yuav tsum tau ua thiab kho cov tshuaj, suav nrog kev sib tsoo, sib tsoo, sib tov, granulation, ziab, ntsiav tshuaj nias, thiab lwm yam, thiab daim ntawv thov ntawm hmoov tshuab yog permeated nyob rau hauv txhua chav ua haujlwm.
Nws yog taw qhia hauv kev lag luam tias kev npaj khoom thev naus laus zis thiab cov khoom siv tshuaj yog qhov kev lees paub rau kev ua haujlwm ntawm cov hmoov thiab cov cuab yeej tseem ceeb kom ntseeg tau tias qhov zoo ntawm cov khoom ua tau npaj zoo. Yog li, nws yog qhov tseem ceeb heev los xaiv cov kev zam uas tsim nyog thiab siv cov cuab yeej tsim nyog npaj thiab khoom siv.
Noj cov txheej txheem kev npaj ntawm cov ntsiav tshuaj ua piv txwv, nws yog ib hom ntsiav tshuaj khov khoom los ntawm kev sib xyaw thiab nias tshuaj thiab cov kev ua kom haum tusyees. Kev npaj txheej txheem ntawm cov ntsiav tshuaj tuaj yeem muab faib ua peb kauj ruam: txhaws, nias thiab thawb. Txhawm rau kom ntseeg tau tias cov ntsiav tshuaj zoo, hauv kev tsim cov qauv thiab cov neeg soj ntsuam, kev cuam tshuam ntawm cov hmoov ntawm cov tshuaj ntawm cov ntsiav tshuaj tsim yuav tsum tau txiav txim siab, suav nrog kev tshuaj xyuas ntawm fluidity, compressibility thiab quantifiable ntawm cov ntaub ntawv ntsiav tshuaj.
Nrog rau kev nthuav dav tshiab tshaj tawm thiab cov khoom siv tshuaj ntsiav nias kom zoo dua, kev tsim tshuaj ntsiav tshuaj tau nkag mus rau hauv lub sijhawm ntawm kev ua haujlwm siab, txuag hluav taws xob thiab zoo. Raws li cov khoom sib txawv ntawm cov hmoov, pelletizing thiab txoj kev nias lossis txoj kev nias ncaj qha feem ntau yog siv hauv cov ntsiav tshuaj nias. Ntawm lawv, granulation thiab ntsiav tshuaj nias txoj kev tuaj yeem muab faib ua ntub dej granulation thiab qhuav granulation.
Tshwj xeeb, kev ntub dej granulation thiab ntsiav tshuaj nias txoj kev muaj qhov yuav tsum tau tsawg ntawm cov hmoov ntawm cov ntaub ntawv raw lossis kev tshaj tawm, uas tuaj yeem daws cov teeb meem ntawm cov hmoov tsis zoo ntawm cov ntaub ntawv raw thiab cov excipients, tau txais cov khoom sib xyaw nrog fluidity zoo, thiab txhim kho cov compression ntawv ntawm tshuaj. Txawm li cas los xij, qhov tsis zoo ntawm cov granulation ntub yog tias nws tsis haum rau cov tshuaj nrog cov cua kub tsis ruaj khov thiab cov av noo, uas yuav ua rau lo cuam tshuam thiab qhov saum toj kawg nkaus hauv cov txheej txheem ntawm cov ntsiav tshuaj compression.
Txoj kev granulation qhuav yog txoj kev ntawm kev zuaj thiab granulating cov sib xyaw kom haum ntawm cov khoom nyoos thiab ntu ua rau daim nyias nyias los yog loj. Kev npliag thiab kev ua kom yooj yim kuj tseem tuaj yeem ua kom zoo dua qub tom qab granulation, uas yog txoj hauv kev zoo rau kev sib txuas ntawm cov tshuaj nrog cov phom sij tsis ruaj khov. Txawm li cas los xij, hom no muaj ntau dua qhov xav tau ntawm cov khoom ntawm excipients hmoov. Excipients yuav tsum muaj zoo yas deformation, zoo compression formability lossis muaj cov haujlwm ntawm cov nplaum qhuav. Txwv tsis pub, nws yooj yim tawg rau hauv cov hmoov thaum tsoo thiab granulating tom qab ntsiav tshuaj nias, thiab cov paib ntawm qhov me me tsis siab.
Xyoo tsis ntev los no, nrog kev txhim kho txuas ntxiv ntawm niaj hnub kev tshawb fawb thiab thev naus laus zis, nrog rau kev txhawb nqa GMP txheej txheem thiab QBD lub tswv yim, cov txheej txheem kev kho hmoov txuas ntxiv mus rau hauv txheej txheem kev npaj ntawm cov khoom npaj tau. Nyob rau tib lub sijhawm, raws li cov txheej txheem npaj khoom thev naus laus zis thiab cov cuab yeej siv tshuaj muaj feem cuam tshuam rau cov khoom lag luam ntawm cov khoom npaj tau ruaj khov, nws yog qhov hloov tshiab rau kev npaj khoom thev naus laus zis thiab txhim kho cov khoom siv tshuaj hauv qab ntawm qhov nce siab xav tau ntawm kev lag luam tshuaj tam sim no rau cov khoom ua npaj khoom lag luam.
Los ntawm qhov pom ntawm qhov sib, qhov kev lag luam ntseeg hais tias hom kev nruam nruam yog kev txhim kho hom tshawb nrhiav thiab xyaum los ntawm ntau cov khoom lag luam npaj tau tam sim no, uas yog, los ntawm kev tsim cov khoom nyoos mus rau kev tsim cov khoom, txhua txheej txheem yog nqa tawm ua ntu zus raws li cov txheej txheem xav tau. Nws xav tias qhov qauv no yuav dhau los ua kev tsim kho ntawm kev lag luam hauv tsib xyoos tom ntej no los yog li ntawd.
Hauv cov ntsiab lus no, qee cov tuam ntxhab, xws li LTPM CHINA, tau ua tiav lawv cov qauv hauv xyoo tsis ntev los no. Piv txwv li, qee qhov kev lag luam tau hais tias nyob rau xyoo 2020, lub tuam txhab yuav tsom rau" tag nrho txoj kev daws teeb meem ntawm cov khoom npaj ntse ntse" thiab cov txheej txheem kev xaiv ntawm kev lag luam kho mob loj, txuas ntxiv kom tob tob rau kev lag luam cov cuab yeej tshuaj ua lag luam thiab kev txawj ntse logistics kev lag luam, sib zog los ua lub ntiaj teb kev daws teeb meem ntawm cov khoom lag luam tshuaj ntse ntse, thiab txuas ntxiv txhawb kev lag luam tob rau kev lag luam kev noj qab haus huv loj.
Qee lub lag luam, dhau los ntawm kev teeb tsa ntau xyoo, tau txhawb lub tswv yim ntawm" ib qho ntsug, ib kab rov tav thiab ib qho platform", txuas ntxiv txuas ntxiv lawv cov khoom kab, txhim kho lawv cov txiaj ntsig kev sib tw hauv kev npaj cov khoom, tsim kev sib tw tag nrho kev daws teeb meem rau kev npaj khoom thiab tsim cov chaw tsim tshuaj lag luam ntse.